Hydrogenated ergot alkaloidsのヒト脳血流量に及ぼす影響—133Xeクリアランス法による検討

EFFECT OF MIXED HYDROGENATED ERGOT ALKALOIDS ON CEREBRAL CIRCULATION. 133XE CLEARANCE STUDY IN MAN

　hydrogenated ergot alkaloidsは末梢血管に作用して血管拡張をおこし，全身血圧を低下させる作用があることが知られている。最近この種のhydrogenated ergotalkaloidsとして，dihydroergocristine, dihydroergo—cryptine, dihydroergocornineのmethanesulfonatesの脳血管系に対する作用についていくつかの報告がみられる。

　この薬剤が末梢血管系に対して血管拡張作用を示すことは確実であるが，その脳血管に対する作用に関しては報告者により成績がまちまちで，とくにヒトの脳血流に対する影響については報告も少ない。

Cerebral blood flow was measured in 16 patients with cerebrovascular disease or posttraumatic com-plaints using the ¹³³Xe intracarotid injection tech-nique. After control measurements were performed, 0.005 to 0.006 mg/kg of Hydergine was adminis-tered intravenously (5 patients). The mean CBF did not change significantly: mean figures were 38 ml/100g/min before the administration, and 38 and 36-37 ml/100 g/min immediately after and 15 minutes after administration, respectively.

In 8 patients, 0.020 to 0.024 mg/kg dose was given. CBF increased from 41 ml/100g/min in the steady state to 45-46 ml/100g/min immediately after and 15 minutes after intravenous Hydergine injection, these changes were statistically significant.

In the remaining 3 patients, Hydergine was given in combination with intramuscular dose of ethyl-phenylephrine hydrochloride.

It is concluded that the intravenous Hydergine in dosis of 0.020 to 0.024 mg/kg increases the CBF significantly.

Generic Names:

Methanesulf onates of dihydroergocristine, dihydro-ergocryptine and dihydroergocornine……Hydergine.

Ethyl-phenylephrine hydrochloride (2-ethyl-amino-1- (3-hydroxyphenyl) -ethanol hydrochlo-ride)……Effortil.