133Xe吸入法による脳血流量測定—CO2負荷法の検討 第I報

CEREBRAL BLOOD FLOW (CBF) WITH 133XE INHALATION METHOD:CBF STUDY DURING CO2 INHALATION

　抄録　9名の正常者と20名の患者を刻象として，¹³³Xe吸入法（Novo-Cerebrograph）にて脳血管のCO₂反応性を検討し，¹³³Xe吸入法による脳血管のCO₂反応性の検討における臨床価値について若干の考察を加えた。

　正常者において，F₁値では若年者群（3名）で40〜44％，中年者群（3名）で36〜37％，老齢者群（3名）で35〜36％の，またISI値では，各々27〜28％，30〜31％，23〜24％の血流量の増加を認めた。CO₂reactivity factor （RF）は，F₁値では各々5.5〜5.8,3.8〜4.0,3.3,ISI値では各々3.1〜3.2,2.0〜3.3，1.2〜1.3であつた。

The effects of CO₂ inhalation on the cerebral blood flow (CBF) were examined with ¹³³Xe inhala-tion method (Novo Inhalation Cerebrograph) on 9 normal peoples and 20 patients. Nine normal peoples were divided into 3 groups consisting ofeach 3 peoples, namely young age group, middle age group, and old age group. Each increased CBF (%) by CO₂ inhalation was 40~44 in young age group, 36~37 in middle age group, and 35~36 in old age group in the blood flow of the first compartment (F₁), and 2728 in young age group, 30~31 in middle age group and 23~24 in old age group in the initial slope index (ISI). Each CO₂ reactivity factor (RF) was 5.5~5. 8 in young age group, 3.8~4.0 in middle age group and 3.3 in old age group in F₁, and 3.1~3.2 in young agegroup, 2.0~2.3 in middle age group, and 1.2~1.3 in old age group in ISI.

Twenty patients consisted of 15 patients of oc-clusive cerebrovascular disease, 2 patients of head injury, 2 patients of normal pressure hydrocephalus and one patient of subarachnoid hemorrhage. RF was abnormally lower than normal value in 5 pa-tients in F₁, but in 7 in ISI.

Clinical benefits of CBF study during CO₂ inha-lation with ¹³³Xe inhalation method were discussed.