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Japanese

EFFECT OF HYDROGENATED ERGOT ALKALOIDS ON CEREBRAL METABOLISM OF THE PATIENTS WITH NEUROLOGICAL DEFICITS AFTER SUBARACHNOID HEMORRHAGE Ikuo Ihara 1 , Keishi Kobayashi 1 , Ryoji Ishii 1 , Tetuso Koike 1,2 , Shigeki Kameyama 1 , Shigekazu Takeuchi 1 , Komei Ueki 1 1Department of Neurosurgery, Brain Reseach Institute, Niigata University pp.195-200
Published Date 1981/2/1
DOI https://doi.org/10.11477/mf.1406204720
  • Abstract
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Cerebral blood flow and metabolism were meas-ured in 9 patients with neurological deficits after subarachnoid hemorrhage using the 133Xe intra ca-rotid injection methods. Regional cerebral blood flow (r-CBF) values were calculated with initial slope method (2 minutes flow index), their values were compared with the blood flow response to ar-terial PCO2 and to administration of hydrogenated ergot alkaloids (HEA). In case of repeated exami-nation nfter short interval CBF values were cor-rected useing the rate of reproducibility. The content of oxygen, glucose, lactate and pyruvate in the arterial and the internal jugular blood were measured, and CMRO2, CMR glucose, CMR lactatevalues were calculated.

1st step: The measurement of r-CBF was per-formed immediately after the infusion of 1.5mg HEA for 15 minutes. The focal ischemic lesions decreased, mean CBF value increased by 8% signi-ficantly, arterio-venous difference of oxygen value increased by 20% significantly and CMRO2 value increased by 26% significanly after HEA adminis-tration.

2nd step: 1.8mg HEA was infused for one week. EEG findings were improved after administration of HEA. The pressure and the lactate levels of cerebrospinal fluid decreased, but the effect of HEA must be carefully distinguished from natural recov-ery.

Administration of HEA increased the CMRO2 values and consequently increased the mean CBF values.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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