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BIPHASIC CHANGES OF CEREBRAL BLOOD FLOW IN EXPERIMENTAL SPASM Mitsuo Sugiura 1 1Department of Neurosurgery, Nagoya University School of Medicine pp.1143-1153
Published Date 1971/10/1
DOI https://doi.org/10.11477/mf.1406202979
  • Abstract
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Serial changes in CBF as well as vital signs following traction or rupture of the posterior communicating artery and blood infusion into the subarachnoid space were observed in dogs.

Following traction of the artery, decrease in CBF was observed for about 20 min. Following blood infusion into the cisterna magna, CBF decreased for 60 to 150 min. Further observation did not show any change.

Following rupture of the artery, CBF decreased and then returned to the base line within 60 to 150 min. After this restoration, CBF revealed a tendency to decrease gradually with the lapse of time. Such a biphasic change in CBF following rupture of the posterior communicating artery might mean that the mechanism lowering CBF in the acute phase of spasm differs from that in the chronic phase. In the acute phase the mechanical traction, fresh blood in the subarachnoid space and increased intracranial pressure might act as the factor producing the vasospasm which lasted for 60 to 150 min. In the chronic phase two etiologic factors might be considered. One is a substance requiring one day or more time to act as a vaso-constrictor, and the other is changes in vasoreacti-vity due to damage of the vessel wall.

When the basilar artery was punctured with a fine needle, spasm observed only at the site of puncture. When blood reached to the circle of Willis through the subarachnoid space, it was veri-fied by cerebral angiography that the whole vas-cular system at the basis constricted markedly.


Copyright © 1971, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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