多発性硬化症の1例

A CASE OF MULTIPLE SCLEROSIS

　多発性硬化症は従来我が国においては極く稀な疾患として考えられて来たが，最近本疾患に対する新しい認識と研究の進歩により我が国においても必ずしも稀な疾患ではないことが立証されて来ている。然しながらその診断の基準については未だ検討の余地がある。我々は臨床上多発性硬化症と考えられる患者についてその経過を観察する機会を得たので茲に報告する。

27-Years-old, male, radio technician Patient initially complained of left ophthalgia and headache. (Jan 3, 1959). After a few days he has had left visual disturbance, numbness on extremities, speach trouble (scanning sp-each) and general malaise, Admission:Jan. 16, 1959. Fundi showed temporal palor of optic disk on left eye and subsequently total palor. About one month later, patient progr-essed to spastic gait associated with slight degree of ataxia. On 12th, March, 1959, following after 2~3 weeks' remission, the disturbance of gait and speach, and vertigo got worse and became distinct. At the ad-vanced stadium of his disease, the cerebellar signs such as Romberg's phenomen, hyper-metria and Nystagmus, and the symptome of the upper motor neuron such as exagger-ation of deep tendor reflexes and pathologic reflexes as Babinski's sign, Chaddock's toe sign and Hoffmann's sign, however, there was no absence of abdominal reflex, no sen-sory disturbance, no bladder and rectal invol vement. Spinal fluid revealed moderate degree of Pleocytosis, and the increased total prot-ein and γ-golbulin. At the end of June, 1959, these symptomes has almost disappeared.