精神疾患に対するAcetylpromazineの使用経験

EXPERIENCE IN TREATMENT OF PSYCHOSES WITH ACETYLPROMAZINE

はしがき

　最近精神疾患に対する薬剤としてPhenothia-zineの誘導体が有効であることが認められて以来それに関する研究が各国に於て行なわれ，諸種の誘導体が次々に製成されると共に広く一般に試みられるようになつた。

　精神疾患が単に生物学的な方法のみによつて満足すべき状態に達することの困難さは充分理解されるが，その治療法の多様性を得られたことは著しい進歩といわざるを得ない。

Acetylpromazine was administered to 10 hospitalized patients (schizophrenia 8, periodic depression 1, mixed psychosis 1 ), in which 9 cases were previously treated with chlorpro-mazine or reserpine. The initial dosage was 20~60mg and increased by increments of 10~20mg. per day until the therapeutic level was reached.

The most effective therapeutic dose was150~180mg. per day. The patients weremaintained on this dosage from 7 to 50 days and then were discontinued gradually.

1. 3 cases were completly, 2 cases were uncompletly and 1 cas, was poorly improved,while 4 cases were unchanged.

2. The physiologic side effects f acetyl-promazine were not so serious and were less than those of chlorpromazine or reserpine.

3. Acetylpromazine is useful in the treat-ment of psychoses such as schizophrenia manifesting delusion, hallucination, poor rap-port or psychomotor retardation.