肝脳疾患特殊型（猪瀬）に対する知見補遺

Two Familial Cases of Inose's Special Type of Hepato-encephalic Disease

　典型的と思われる肝脳疾患特殊型（猪瀨）の家族的に発生した2例について病理学的，生化学的検索を行つた結果について述べた。

　（稿を終るに当り，猪瀨教授，吉田教授，河合講師，に非常にお世話になったことを附記し感謝の意を表しておく）

Two familial cases of Inose's special type of hepato-encephalic disease are reported which has recently been studied by Inose in comparison with an ordinary hepato-encephalic degeneration.

1) They have'a typical mental symptom: a progressive mental deterioration with periodi-cally recurring disorders of consciousness. They have no extrapyramidal symptoms.

2) Their E.E.G. consists of high-voltage slow waves both in comatose and normal states.

3) The case I shows typical histopathological changes in his liver and brain, i.e., pseudo-livercirrhosis, pathological changes in glia-cells (so-called Arzheimer's II type of glia-cell containig a granule stinable with Best's carmin solution), and a sponginous and softe-ning area.

4) A biochemical study on case II. the younger brother of case I, has revealed the following findings: a) No abnormalities found in Cu.-meta- bolism.

b) Total amino-acid in the urine is not constant, being subject to clinical symptoms: the worse the clinical symptoms, the more urinal amino-acid is excreted.