Rapid Improvement of Callosal Edema by Thiamine Administration in Marchiafava-Bignami Disease : A Case Report Yoshimasa Kinoshita 1 , Hideoki Yasukouchi 1 , Eichi Tsuru 1 , Toshio Okudera 2 , Akira Yokota 2 1Department of Neurosurgery, Munakata Suikokai General Hospital 2Department of Neurosurgery, University of Occupational and Environmental Health Keyword: Marchiafava-Bignami disease , thiamine deficiency , diffusion-weighted image pp.425-428
Published Date 2004/5/1
DOI https://doi.org/10.11477/mf.1406100285
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 Marchiafava-Bignami disease(MBD)associated with chronic alcoholism is a fatal disorder characterized by demyelination of the corpus callosum. A 62-year-old Japanese man, a heavy drinker for his last over 10 years, was admitted to our hospital because of acute onset of speech disturbance. The first MR images showed abnormal signal intensity of the corpus callosum, which was a typical finding of MBD, but no signal abnormality on diffusion-weighted images. At three days after large doses of thiamine administration, MR studies revealed the disappearance of callosal high signal intensity. His symptom gradually improved, the pathogenesis and therapy of MBD were discussed.

(Received : January 19, 2004)

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