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Three Cases of Schizophrenia with Pericentric Inversion on Chromosome 9 Hiroshi KUNUGI 1 , Shinichiro NANKO 1 , Rie IYO 1 , Junko MORIDAIRA 1 , Hajime KAZAMATSURI 1 1Department of Psychiatry, Teikyo University School of Medicine Keyword: Schizophrenia , Genetics , Chromosome 9 , Chromosomal abnormality , Pericentric inversion pp.257-263
Published Date 1994/3/15
DOI https://doi.org/10.11477/mf.1405904998
  • Abstract
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 Three cases of schizophrenia according to the DSM-Ⅲ-R criteria with pericentric inversion on chromosome 9 [inv. (9) (p11; q13)] were reported. Case 1 was a divorced housewife and herillness began at the age of 28 years. She presented auditory and visual hallucination which were well controlled by neuroleptics. Case 2 was a female student. She was referred to our psychiatric clinic at the age of 15 when she appeared to be in a depressive state based on personality disorder. She was admitted to our hospital, and later she developed an acute psychotic state presenting delusion of persecution, auditory hallucination, and psychomotor excitement. The diagnosis of her illness changed to schizophrenia. Her symptoms were so irresponsive to neuroleptics that it took 3 years of hospitalization until she remitted. Brain computerized tomography scan revealed no abnormalities in case 1 and 2. Case 3 was a male college student who presented auditory hallucination, delusion of persecution, and catatonic symptoms. His age at the onset was 19 years old. He was admitted to the hospital.

 No specific physical abnormalities were found in the three cases. The courses and subtypes of the cases varied from one another. They had no family members with schizophrenia among their first degree relatives. However, it can not be denied that there is a possibility that inv. (9) was one of the genetic etiological factors making these subjects vulnerable to schizophrenia. Accumulation of cases with the same chromosomal abnormality, and linkage studies between DNA markers on chromosome 9 and schizophrenia are indicated.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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