雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

Seishin Igaku Volume 37, Issue 6 （June 1995）

精神医学 37巻6号（1995年6月発行）

Japanese English

短報

Pimozideにより低ナトリウム血症を呈した精神分裂病の1例 A Female Case of Schizophrenia who Presented Hyponatremia induced by Pimozide 西村浩 ¹ , 町田勝彦 ¹ , 中野浩志 ² , 篠崎徹 ² , 笠原洋勇 ² , 牛島定信 ² , 鈴木みね子 ³ , 斎藤洋 ³ , 柏木秀彦 ⁴ , 奥田丈二 ⁴ Hiroshi NISHIMURA ¹ , Katsuhiko MACHIDA ¹ , Hiroshi NAKANO ² , Tooru SHINOZAKI ² , Hiroo KASAHARA ² , Sadanobu USHIJIMA ² , Mineho SUZUKI ³ , Hiroshi SAITOH ³ , Hidehiko KASHIWAGI ⁴ , George OKUDA ⁴ ¹東京慈恵会医科大学臨床検査医学教室 ²東京慈恵会医科大学柏病院精神神経科 ³鳳生会成田病院精神神経科 ⁴東京慈恵会医科大学内科 ¹Department of Laboratory Medicine, The Jikei University School of Medicine ²Department of Psychiatry, The Jikei University School of Medicine Kashiwa Hospital ³Department of Psychiatry, Narita hospital ⁴Department of Internal Medicine, The Jikei University School of Medicine キーワード： Pimozide , Compulsive water drinking , Water intoxication , Schizophrenia , Hyponatremia Keyword: Pimozide , Compulsive water drinking , Water intoxication , Schizophrenia , Hyponatremia pp.657-660

発行日 1995年6月15日 Published Date 1995/6/15

DOI https://doi.org/10.11477/mf.1405903894

PDF(3937KB)

有料閲覧

Abstract 文献概要
1ページ目 Look Inside

　我々は外来通院中に水中毒により血中ナトリウム値が118mEq/lとなり，重度意識障害，けいれん発作および噴出性嘔吐などを来した精神分裂病の61歳女性例を経験した。原因薬剤はpimozideと考えられたが，本剤による低ナトリウム血症は我々の知るかぎりでは小児科での精神発達遅滞3例が報告されているだけで，精神科分野での報告を見い出せなかったため，文献的考察も併せて報告する。

　With the view of recording it in medical literature, we report a case of an outpatient with schizophrenia who presented hyponatremia induced by pimozide. The patient was a 61-year-old Japanese female who had taken 2 mg/day of pimozide for more than 20 years since 1974 because of auditory hallucination and delusions of persecution. In June of 1994, she suddenly showed disturbance of consciousness, speech disturbance, gait disturbance, convulsion and projectile vomiting. Laboratory data showed 118 mEq/ l of serum natrium, 10,800/mm³ of WBC, 376×10⁴/mm³ of RBC, 11.4g/d/ of Hb and 33.5% of Ht. Computed tomography examination showed a slightly edematous image of the brain but there was no bleeding. After admission, her general condition immediately improved with slow correction of serum hyponatrium by fluid therapy. On the 8 th day she was discharged without any symptoms or remaining abnormal laboratory data.

　There have been reports that haloperidol, fluphenazine, thioridazine, amitriptyline, desipramine and carbamazepine have induced compulsive water drinking, water intoxication and hyponatremia, but, to our knowledge, there has been only one report of pimozide-induced hyponatremia in the field of pediatrics and no previous report in psychiatry.