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Two Cases of Pathologic Laughing Improved by Haloperidol Hajime Sakugawa 1 , Hirokazu Uechi 1 1Department of Neuropsychiatry, College of Medicine, University of Ryukyus pp.654-657
Published Date 1982/6/15
DOI https://doi.org/10.11477/mf.1405203431
  • Abstract
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 Two cases were reported, in which haloperidol improved pathologic laughing occurred after the rupture of the cerebral aneurysm.

 In the first case, low density areas were seen on the right posterior part of the frontal, the parietal and the temporal on C.T. scan. The pathologic laughing almost disappeared by oral administration of haloperidol and the laughing did not appear after stopping it.

 In the second case, ligation of the ruptured aneurysm on the left anterior cerebral artery and ventricle-peritoneal shunt were performed. A low density area was seen at the frontal lobe, but no pathologic laughing appeared. After 28 months, loss of consciousness occurred. Several days after recovery from the loss of consciousness, pathologic laughing began, but oral administration of haloperidol improved this symptom remarkably. on CT scan, another low density area came out in the upper part of the anterior limb of the internal capsule.

 These two cases were discussed from the aspects of brain pathology and psychopharmacology.


Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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