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A Case of Delusional Disorder with Abnormal Encephalographic Findings Induced by Low-dose Quetiapine Treatment Matsuhiko OKA 1 , Yasuya NAKATO 1 , Yuki OMIYA 1 , Gota KAWAI 1 , Rie KAMEYAMA 1 , Tsugiko KURITA 1 , Kotaro SAKURAI 1 , Shin NAKAGAWA 1 , Takeshi INOUE 1 , Tsukasa KOYAMA 1,2 1Department of Psychiatry, Hokkaido University Hospital, Sapporo, Japan 2Ohyachi Hospital Keyword: Quetiapine , Olanzapine , Abnormal electroencephalogram , Delusional disorder pp.139-143
Published Date 2013/2/15
DOI https://doi.org/10.11477/mf.1405102383
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 A 25-year-old Japanese woman with delusional disorder but no significant medical history, had EEG abnormalities while taking 100mg quetiapine. On an awake recording, diffuse high-voltage slow waves were frequently observed in the bifrontal area. Seizures did not occur, no other toxic, metabolic, or anatomical abnormalities were identified to cause the EEG abnormalities. The EEG abnormalities improved immediately after discontinuing quetiapine, and were not observed after switching to 5mg olanzapine. As with other antipsychotics, even low dose of quetiapine should be used with caution. When EEG abnormalities are observed, it is necessary to eliminate the offending drug or switch to other drugs.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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