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A Case of Sertraline Induced Tardive Dyskinesia with Senile Depression Aki KURAMASHI 1 , Yuto UEDA 1 , Toshihide USHIRO 2 , Mitsutaka UDAGAWA 3 , Yasushi ISHIDA 1 1Department of Psychiatry, Miyazaki University, Miyazaki, Japan 2Miyazaki Prefectural Fuyoen Hospital 3Daigo Hospital Keyword: Senile depression , Sertraline , Tardive dyskinesia pp.425-429
Published Date 2009/5/15
DOI https://doi.org/10.11477/mf.1405101415
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 Tardive dyskinesia (TD) is a side effect of treatment with neuroleptics. A number of hypotheses have been proposed to explain the mechanism of neuroleptic-drug-induced TD, induding hypersensitivity of striatal dopamine D2 receptors caused by prolonged blockage and upregulation of the receptor, and neuronal disturbance caused by hyperactivity of cholinergic neurons. However there are few reports a TD induced by serotonin selective reuptake inhibitors (SSRI).

 A 72-year-old woman with senile depression was treated with fluvoxamine and modified electroconvulsive therapy. However, the depressive state recurred. Since the depressive condition was not improved by fluvoxamine, the patient was administered sertraline, which was followed by discontinuation of fluvoxamine administration. Four months later, the patient experienced involuntary movements of the lips and tongue, indicating TD that was probably induced by sertraline. Sertraline administration was changed to fluvoxamine, and the oral dyskinesia immediately disappeared. On the basis of the clinical course of this patient, we discussed the mechanism of sertraline-induced TD in this report.


Copyright © 2009, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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