放射光を用いた微小心筋領域血流計測法の測定精度

Precision of the Small Regional Flow Measurement using Synchrotron Radiation

　われわれは単色化放射光を線源としたX線蛍光分析法で安定重元素をラベルしたマイクロスフェアーを解析する血流計測法を開発した．この方法では，放射性マイクロスフェアー法よりもさらに小さい領域（10mg）の血流計測を組織を小片に分割せずに実現することができる．相対血流量の計測誤差は約10％であった．

We developed a monochromatic synchrotron radia-tion-excited system for 2-dimensional mapping of X-ray fluorescence evoked from heavy element-loaded microspheres, and evaluated the small regional flow in the short axial myocardial slices of the left ventricle in 5 dogs. The methodological error (average of % difference between the dual flows measured by 2 simul-taneous sets of microspheres, etc) was about 10 %. We cocluded that this system can measure a relatively smaller regional flow than that evaluated by the radio-active michrosphere method with a sufficiently small methodological error. It should be useful for the precise evaluation of local continuity of flow.