The Effects of Pharmacological Autonomic Blockade on the Conduction System in Patients with and without Sinus Node Dysfunction Yukiko Tsuchioka 1 , Wataru Shimizu 1 , Shinji Karakawa 1 , Junko Mukai 1 , Kenji Nagata 1 , Togo Yamagata 1 , Mitsunori Okamoto 1 , Hideo Matuura 1 , Goro Kajiyama 1 1First Department of Internal Medicine, Hiroshima University School of Medicine Keyword: 洞機能不全症候群 , 刺激伝導系 , 薬理学的自律神経遮断 , sinus node dysfunction , conduction system , pharmacological autonomic blockade pp.153-158
Published Date 1993/2/15
DOI https://doi.org/10.11477/mf.1404900617
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Electrophysiological studies were performed in 26 patients with sick sinus syndrome (SSS) and 12 controls before and after pharmacologic autonomic blockade (PAB) with propranolol (0.15 mg/kg) and atropine (0.04 mg/kg). Sinus cycle length (SCL) shortened sig-nificantly after PAB in both groups. PA and HV inter-vals did not change after PAB. AH interval shortened and Wenckebach period increased after PAB in SSS group. Maximum corrected sinus node recovery time shortened in the control group but did not change in the SSS group after PAB. Calculated sinoatrial conduction time shortened after PAB in both groups.

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