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Acute effects of nifedipine in severe heart failure: hemodynamics, plasma catecholamine levels, renin activity, metabolisms and blood gas date Yoshinori Morimoto 1 , Takeshi Nakano 2 , Yutaka Kakuta 1 , Takao Koyama 3 , Takashi Kodera 3 , Masayasu Kanamaru 3 , Tokuji Konishi 2 , Hideo Takezawa 2 1Cardiac Department, Yamada Red Cross Hospital 2The 1st Department of Internal Medicine, Faculty of Medicine, Mie University 3Department of Internal Medicine, Chusei General Hospital pp.439-444
Published Date 1986/4/15
DOI https://doi.org/10.11477/mf.1404204858
  • Abstract
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 Simultaneous estimation of hemodynamics, catecholamine levels, metabolism and blood gas data were performed in 9 patients with severe heart failure before and 1 hr after administration of sublingual 10 mg Nifedipine.

 CI increased from 2.58 L/min/M2 to 3.09 L/min/M2 (+ 25%, <0.01), SVI 32 ml/beat/M2 to 39 ml/beat/M2 (+ 20%, <0.02), Noradrenaline 0.59 ng/ml to 0.68 ng/ ml (+33%, <0.02), PCWP decreased from 22 mmHg to 17 mmHg (-23%, <0.001), PAm 29mmHg to 24mmHg (-19%, <0.001), RA 10 mmHg to 6 mmHg (-45%, <0.001), BPm 106 mmHg to 88 mmHg (-21%, <0.01), SVRI 3, 106 dynes・sec・cm-5. M2 to 2,160 dynes・sec・cm-5. M2 (-28%, <0.01), Double products 11,879 to 9,727 (-15%, <0.05), A-VO2 5.4 ml/dl to 4.7 ml/dl (-14%, <0.001), whereas there was no significant change in heart rate, Renin activity, Aldosterone, Adrenaline, Lactate/Pyruvate and blood gas (pH, P02, PCO2, BE). Therefore Nifedipine seemed to be a potent vasodilator with both acting as afterload and preload reduction and so to be useful for the treatment of severe heart failure as a deloading agent.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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