虚血性心疾患患者の血液粘度と酸素解離能との関連

Blood viscosity oxygen dissociation activity in ishemic heart diseare

　心筋虚血を伴う虚血性心疾患患者において，その低下した冠血流を改善するため血液の粘性の低下と酸素解離能が促進しているか否かは興味のもたれるところである。そこで，著者らは各種虚血性心疾患患者の全血粘度と酸素解離能とを同時に測定し，それらの因子が如何に相互に関与しうるか否かについて検討した。

Blood viscosity and oxgen dissociation activity in patients with angina pectoris, myocardial infarction and healty subjects were studied. Blood viscosity at low shear rate increased with aging in angina pectoris patients (AP group) and myocardial infarction patients (MI group), but decreased with aging in healty subjects (N group). Oxgen dissociation activ-ity tended to decrease with aging in AP and MI groups, whereas it tended to decrease with aging in N group. There was negative correlations be-tween blood viscosity and oxgen dissociation activity in all groups. However, it was the strongest in AP group (p<0.002). Interestingly, there were three cases of middle aged who prominently conducted the regulatory system in acute phase of myocardial infarction, another three cases with high aged who unoperated this system in late phase of myocardial infarction.