ECMOの生体肺に与える影響—摘出肺内水分量と呼気圧量曲線

Studies on the pulmonary extravascular water volume and the deflation pressure volume curve of lung extirpated from goat subjected to prolonged extracorporeal membrane oxygenation

　重症呼吸不全患者に対するECMOの臨床応用^1）が普及しない原因の一つは，ECMO自体の安全性が今一歩不足しているためと思われる。著者らはECMOの安全性確立のため数年来研究をかさね^2,3），ヤギを用いた最長38日間までのECMOに成功した。これら長期EC—MOの肺に与える影響として摘出肺内水分量および呼気圧量曲線を測定したので報告する。

Effect of prolonged ECMO on the pulmonary extravascular water volume (PEWV) and the defla-tion pressure volume curve of lungs extirpated from goat was studied. PEWV was measured by a desic-cation method. When pure oxygen was used to ven-tilate the membrane lung, PEWV increased. This rise was more conspicuous when the bypass flow was increased, though the increase of PEWV was not so much as to hamper the deflation pressure volume curve of the extirpated lungs.