実験的心筋硬塞に対する人工血液（Fluosol-DA）の効果

The effects of Fluosol-DA on the experimental myocardial infarction in dogs

　血液ガス運搬体としてのPerfluorochemical乳剤は，近年その有効性と安全性が，物理，化学，生物学的基礎研究により充分検討され，広範囲な臨床応用の可能性も近いと考えられている^3）〜6）。

　現在Perfluorochemical乳剤（以下，PFC乳剤）の臨床応用として考えられているものは，①外傷による大出血，②消化管大出血，③大出血が予想される手術，④体外循環のPFC乳剤による無血充填，⑤全血交換（劇症肝炎等），⑥移植臓器保存，⑦一酸化炭素中毒の救命，⑧臓器灌流による臓器機能，ホルモンや化学物質の作用に関する基礎的研究等が考えられている。

In recent years, many attentions have been paid for salvaging ischemic myocardium by pharmacological and surgical intervention. Above all Fluosol-DA is thought to be one of the promising chemicals for perfusing myocardium because of sufficient oxygen carrying capacity, suitable particle size and viscosity for micro-circulation. We have been investigated the hemo-dynamics, biochemical and pathomorphological effects of Fluosol-DA on the experimental myo-cardial infarction in dogs. These data was compared with the effects of HES and Heparin infusion.

Following production of myocardial ischemia, LVEDP showed rapid elevation and reached its peak within 3 minutes in all groups. However, it gradually decreased to the normal level at the end of 120 minutes of Fluosol-DA infusion, where as they remained elevated at the peak levels in the HES and Heparin infusion groups. At the end of 2 hours following Fluosol-DA infusion, max dp/dt showed a tendency to recover to the normal level, on the other hand, those of HES and Heparin group showed further decreases.