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開心術の際に,末梢循環不全防止の目的で,α—blockerが用いられ,有効なことが報告されている1〜7)。われわれも同様の目的で,phenoxybenzamine (POB)を体外循環開始前より使用し,良好な成績を収めてきた8)が,高度の肺高血圧を伴う心室中隔欠損症(VSD)および両大血管右室起始症(DORV)の術中ならびに術後の検索により,POBは肺血管抵抗をも減少せしめることを知ったので,その成績について述べ,2,3の考察を加えたい。
Of 153 cases undergoing corrective heart surgery with extracorporeal circulation using phenoxybenzamine (POB) from June 1971 to July 1977, 20 cases with ventricular septal defect and pulmonary hypertension (VSD+PH) and 5 cases with double outlet right ventricle and pulmonary hypertension (DORV+PH) were sub-jected to this study.
The ratios of pulmonary to systemic arterial pressures (Pp/Ps) and vascular resistances (Rp/Rs) were measured before, immediately after and one month after correction.
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