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Autoregulation of Organ Circulation:Artery Dilatation Theory toward Autoregulation Tasuku Nakada 1 1Research Institute for Tuberculosis, Leprosy and Cancer, Tohoku University pp.79-86
Published Date 1968/1/15
DOI https://doi.org/10.11477/mf.1404201864
  • Abstract
  • Look Inside

Pulmonary circulation was compared with that of parenchymal organs, especially with renal circulation. There is a great difference between them at high arterial pressure. A new model of renal circulation was made. Thin rubber tube standing for arterial vessel, narrow glass tubes for arterioles, cuffs for capillaries and a thin rubber tube for venous vessel were connected in a plastic box which represents a capsel. The box was filled with saline as tissue fluid. When the renal arterial pressure increases, blood flow also increases, however rubber tube (arterial vessel) became inflated due to the resistance of glass tubes, and subsequently the cuff and the rubber tube (venous vessel) were flattend becauseof the increase of intra-capsular pressure. It was recognized that the venous pressure is ineffective when venous pressure is lower than the tissue pressure. Tissue pressure rises when the arterial pressure increases.

When arterial pressure increases more than some level, arterial-tissue pressure difference becomes constant independent of the arterial level.

It means the blood flow becomes constant, namely autoregulation appears.

This phenomenon was demonstrated by both perfusion of this model and of saline-filled lung in a box. On reflection, I empha-size that the lung circulation is a special case of organ circulation: when pulmonary arterial pressure increases, the volume of arterial vessels also increase due to resistance of arteriola, but there is no effect on the tissue pressure, namely alveolar pressure. Because the tissue pressure leaks out into alveoli and trachea and then to the atmos-phere.


Copyright © 1968, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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