Coronary Artery Plaque Assessment before and after Statin Therapy using Volcano Therapeutics’ Virtual HistologyTM IVUS:A case report Kazuki Ito 1 , Akihiro Azuma 2 , Masahiro Koide 1 , Takuya Taniguchi 1 , Hirokazu Yokoi 1 , Reo Nakamura 1 , Hidekazu Irie 1 , Noriyuki Kinoshita 1 , Takahisa Sawada 2 , Jun Asayama 2 , Hiroaki Matsubara 2 1Department of Cardiology, Kouseikai Takeda Hospital 2Department of Cardiology, Kyoto Prefectural University of Medicine Keyword: 血管内超音波法 , スタチン , virtual histology , IVUS , statin , virtual histology pp.1263-1268
Published Date 2006/11/1
DOI https://doi.org/10.11477/mf.1404100496
  • Abstract
  • Look Inside
  • Reference

 A 58-year-old man was admitted to our hospital for evaluation of chest oppression on effort. Coronary angiography revealed eccentric 75% stenosis in the left main coronary trunk segment. Volcano Therapeutics’ Virtual HistologyTM intravascular ultrasound(VH IVUS) showed that the cross-sectional vessel area was 21.1mm2, plaque area was 15.8mm2, fibrous tissue was 66%, fibro-fatty tissue was 11%, necrotic core tissue was 20% and dense calcium tissue was 2%. Lipid lowering therapy was continued with the aim of plaque stabilization using simvastatin 20 mg/day. Three months later,VH IVUS was re-performed and showed that the cross-sectional vessel area was 21.5mm2, plaque area was 16.4mm2, fibrous tissue was 56%, fibro-fatty tissue was 42%, necrotic core tissue was 2%. The plaque volume had not decreased, but the percentage of necrotic core tissue in the plaque was reduced from 20 to 2, and the percentage of fibro-fatty tissue had increased from 11 to 42. These changes suggested stabilization of the plaque composition. VH IVUS might be useful in assessment of plaque composition after lipid lowering therapy.

Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院