Japanese

Coronary Artery Plaque Assessment before and after Statin Therapy using Volcano Therapeutics’ Virtual HistologyTM IVUS:A case report Kazuki Ito 1 , Akihiro Azuma 2 , Masahiro Koide 1 , Takuya Taniguchi 1 , Hirokazu Yokoi 1 , Reo Nakamura 1 , Hidekazu Irie 1 , Noriyuki Kinoshita 1 , Takahisa Sawada 2 , Jun Asayama 2 , Hiroaki Matsubara 2 1Department of Cardiology, Kouseikai Takeda Hospital 2Department of Cardiology, Kyoto Prefectural University of Medicine Keyword: 血管内超音波法 , スタチン , virtual histology , IVUS , statin , virtual histology pp.1263-1268
Published Date 2006/11/1
DOI https://doi.org/10.11477/mf.1404100496
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 A 58-year-old man was admitted to our hospital for evaluation of chest oppression on effort. Coronary angiography revealed eccentric 75% stenosis in the left main coronary trunk segment. Volcano Therapeutics’ Virtual HistologyTM intravascular ultrasound(VH IVUS) showed that the cross-sectional vessel area was 21.1mm2, plaque area was 15.8mm2, fibrous tissue was 66%, fibro-fatty tissue was 11%, necrotic core tissue was 20% and dense calcium tissue was 2%. Lipid lowering therapy was continued with the aim of plaque stabilization using simvastatin 20 mg/day. Three months later,VH IVUS was re-performed and showed that the cross-sectional vessel area was 21.5mm2, plaque area was 16.4mm2, fibrous tissue was 56%, fibro-fatty tissue was 42%, necrotic core tissue was 2%. The plaque volume had not decreased, but the percentage of necrotic core tissue in the plaque was reduced from 20 to 2, and the percentage of fibro-fatty tissue had increased from 11 to 42. These changes suggested stabilization of the plaque composition. VH IVUS might be useful in assessment of plaque composition after lipid lowering therapy.


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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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