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Histopathological Characteristics of Esophageal Endoscopic Submucosal Dissection Scar Kazuyuki Ishida 1 , Keiichiro Abe 2 , Kenichi Goda 2 1Department of Diagnostic Pathology, Dokkyo Medical University, Tochigi, Japan 2Department of Gastroenterology, Dokkyo Medical University, Tochigi, Japan Keyword: 食道癌 , ESD瘢痕近傍 , 扁平上皮癌 , 表層分化型 , 錯角化 pp.259-266
Published Date 2023/3/25
DOI https://doi.org/10.11477/mf.1403203133
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 An ESD(endoscopic submucosal dissection)scar is an area of subepithelial fibrosis caused by esophageal ESD, with or without muscularis mucosae. Four patients with squamous cell carcinoma in the esophageal ESD scar were examined as ESD scar carcinoma. All carcinomas were of clear regional characteristics, invading the lamina propria but not the vascular vessels. Two cases were superficially differentiated carcinomas with a tendency toward superficial differentiation and marked cellular atypia mainly on the basal cell layer, and the other two cases had similar components. Hyperparakeratosis was also seen in all cases, and two of them had more extensive lesions than the area that failed to retain Lugol-iodine. Overexpression of p53 was observed in two cases and was useful for tumor identification. Accumulating cases while defining ESD scars and ESD scar carcinoma is necessary to clarify the histopathological characteristics of ESD scar carcinoma.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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