食道扁平上皮癌における逆流性食道炎と飲酒，喫煙の関連

Association of Alcohol Drinking and Smoking with Reflux Esophagitis in Squamous Cell Carcinoma of the Esophagus

要旨●食道扁平上皮癌と逆流性食道炎の関連性を調査する目的で，当センターで経験した20例の食道癌症例を用いて検討を行った．食道胃接合部の病理組織学的検索が十分に可能な症例を用い，下部食道にまだら不染を伴う＋群と伴わない−群に分け，それぞれの症例におけるBarrett粘膜長，噴門腺長および病変の部位について比較した．また，両群で逆流性食道炎と飲酒，喫煙の関連についても検討した．＋群ではBarrett粘膜長が−群より長く，下部食道のまだら不染は逆流性食道炎との関連が疑われた．−群では癌の発生部位が＋群よりやや肛門側に位置する傾向が認められた．また，−群では飲酒，喫煙の関連しない食道癌が5例あり，4例が女性であった．そのうち3例は胸部下部食道に癌が存在していた．

　To investigate the association between esophageal squamous cell carcinoma and reflux esophagitis, we recruited 20 esophageal cancer cases at our center. We divided the patients into two groups：the positive group with speckled iodine staining in the lower esophagus and the negative group without speckled iodine staining in the lower esophagus. Subsequently, we examined the relationship between the two groups and Barrett's mucosa length, cardiac gland length, location of lesions, alcohol drinking, and smoking. A remarkably longer Barrett's mucosa length was observed in the positive group than in the negative group, and speckled iodine staining of the lower esophagus was suspected to be related to reflux esophagitis. Moreover, the location of the lesion in the negative group was lower than that in the positive group. The five esophageal cancer cases showed no history of alcohol drinking or smoking ; four were female. Moreover, the lesions of three out of the four cases were in the lower thoracic esophagus.