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Pathological and Molecular Features of Primary Small Intestinal Cancer Shigeki Sekine 1 1Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo Keyword: 原発性小腸癌 , 管状腺癌 , ミスマッチ修復異常 , APC変異 , Lynch症候群 pp.765-770
Published Date 2022/5/25
DOI https://doi.org/10.11477/mf.1403202909
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 Primary small intestinal cancer constitutes less than 3% of gastrointestinal malignancy, and particularly, jejunal and ileal cancers are exceedingly rare, comprising less than half of all small intestinal cancers. Histologically, the majority of small intestinal cancers are intestinal-type tubular adenocarcinoma but other histological variants, including mucinous adenocarcinoma and medullary carcinoma also occur. Immunohistochemically, small intestinal adenocarcinoma often exhibits a cytokeratin expression pattern different from normal epithelium ; therefore, immunohistochemical examination to distinguish between primary and metastatic tumors requires careful interpretation. Although small intestinal cancer has many genetic alterations common to colorectal cancer, the prevalence of APC mutations is significantly lower, suggesting the distinct molecular background. Also, approximately 20% of small intestinal cancers show mismatch repair deficiency, which may have clinical relevance.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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