Pathology of “Hand-shaking/Crawling-type” Adenocarcinoma of the Stomach Shigeki Sekine 1 , Taiki Hashimoto 1 1Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo Keyword: 手つなぎ癌 , 横這い型癌 , 低分化腺癌 , RHOA , 分岐吻合 pp.1323-1328
Published Date 2021/9/25
DOI https://doi.org/10.11477/mf.1403202558
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 “Hand-shaking/Crawling-type” adenocarcinoma often resembles complete-type intestinal metaplasia and exhibits characteristic branching and anastomosing glands. These lesions endoscopically show an indistinct border, and their biopsy diagnosis is often difficult due to their low-grade histology. Thus, understanding the clinicopathological features of this adenocarcinoma is essential for making an accurate diagnosis. Recently, we conducted a mutation analysis of “hand-shaking/crawling-type” adenocarcinomas and identified RHOA mutations in half of the cases. In this article, we review the histological and molecular features of “hand-shaking/crawling-type” adenocarcinoma, including recent study results.

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