Endoscopic and Pathologic Features of Foveolar-type Gastric Neoplasm Kotaro Shibagaki 1 , Tsuyoshi Mishiro 2 , Chika Fukuyama 2 , Yusuke Takahashi 2 , Satoshi Kotani 2 , Naoki Oshima 1 , Kosaku Kawashima 2 , Norihisa Ishimura 2 , Mamiko Nagase 3 , Asuka Araki 3 , Kyuichi Kadota 3 , Shunji Ishihara 2 1Endoscopy Division, Shimane University Faculty of Medicine Hospital, Izumo, Japan 2Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Japan 3Department of Pathology, Shimane University Faculty of Medicine, Izumo, Japan Keyword: 胃癌 , 胃型形質 , 腺窩上皮型 , ラズベリー様 , Helicobacter pylori pp.1287-1298
Published Date 2021/9/25
DOI https://doi.org/10.11477/mf.1403202555
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 We analyzed the clinicopathological characteristics of foveolar-type gastric neoplasm in H. pylori(Helicobacter pylori)-naïve and H. pylori-infected patients. The naïve patients showed raspberry-like small polyps in the non-atrophic oxyntic gastric compartment on white-light endoscopy. NBI-ME(narrow band imaging with magnification endoscopy)revealed irregularly shaped papillary/gyrus-like microstructures. The infected patients demonstrated larger and more irregular protruded forms than the naïve patients. NBI-ME revealed the presence of highly irregular papillary/gyrus-like microstructures. Histologically, the naïve patients possessed an intraepithelial lesion and predominantly corresponded to low-grade dysplasia as per the World Health Organization classification. However, regardless of the histologic atypical grade, Ki-67 was overexpressed in the lower and middle layers of the neoplasm. The infected patients exhibited severe architectural and cellular atypia, and some showed cellular de-differentiation and lymphovascular invasion.

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