Clinicopathological and Molecular Features of Sporadic Gastric Intraepithelial Foveolar Type Neoplasia Tamotsu Sugai 1 , Noriyuki Uesugi 1 1Division of Molecular Diagnostic Pathology, Department of Pathology, School of Medicine, Iwate Medical University, Shiwa-gun, Yahaba-cho, Japan Keyword: 胃癌 , 腺窩上皮型腫瘍 , 粘液形質 , 分子異常 pp.1275-1285
Published Date 2021/9/25
DOI https://doi.org/10.11477/mf.1403202553
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 Gastric IEFN(intraepithelial foveolar type neoplasia)is not well defined. In this study, we assessed clinicopathological characteristics and molecular alterations associated with the development of IEFN in relation to the conventional low grade neoplasia(intestinal type neoplasia). The clinicopathological and molecular features that were examined included mucin phenotype, AI(allelic imbalance)status, CDX2 expression, p53 overexpression, β-catenin intranuclear accumulation, and MSI(microsatellite instability). First, the findings revealed that the mucin phenotype was gastric mucin phenotype, which was characterized by the expression of MUC5AC. In addition, high expression of CDX2 was revealed in IEFN. Second, low frequency or no overexpression of p53 as well as intranuclear expression of β-catenin were observed in IEFN. Moreover, low or intermediate DNA methylation was frequently observed in IEFN. Finally, high levels of AI, which is an indicator of the malignant potential of tumor cells, were closely associated with IEFN. These findings suggested that IEFN could be an independent entity in terms of pathological findings and molecular alterations, including the presence of multiple AIs.

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