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要旨●初回治療としてESD/ELPSを施行した中・下咽頭表在癌115症例を対象とし,治療成績を検討した.一括切除率は96.8%であった.治療後の狭窄・嚥下障害を6例に認めた.内視鏡治療後は“resect and watch strategy”の方針とした.後発リンパ節転移を9例に認め,そのうち8例は脈管侵襲陽性例であった.局所再発を1例に認めたが,内視鏡治療可能であった.異時多発病変を25例に認め,累積発生割合は3年で25.8%であった.5年全生存割合は86.7%,5年疾患特異生存割合は97.7%であった.ESD/ELPSは中・下咽頭表在癌に対する有用な低侵襲治療であるが,食道入口部近傍の広範囲切除例では術後狭窄に注意が必要であり,その適応は慎重に判断するべきである.
This study included 115 patients who were treated from March 2005 to December 2016 in our cancer referral center. The en bloc and R0 resection rates were 96.8% and 53.5%, respectively. Pharyngeal stenosis and aspiration pneumonia were observed in six patients, and local recurrence was observed in one. Lymph node metastasis after endoscopic resection occurred in nine patients. With a median follow-up period of 37 months, the overall 5-year and cause-specific survival rates were 86.7% and 97.7%, respectively. Further studies are needed to identify indications for the endoscopic wide resection of lesions that may cause pharyngeal stenosis.
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