Diagnosis of Gastritis Using Serologic Markers Kazuhiko Inoue 1 , Tomoari Kamada 2 , Machi Tsukamoto 1 , Noriaki Manabe 3 , Naohito Yamashita 1 , Hiroaki Kusunoki 1 , Keisuke Honda 1 , Yoshinori Kushiyama 4 , Jiro Hata 3 , Akiko Shiotani 2 , Ken Haruma 5 1Department of General Medicine, Kawasaki Medical School, Kurashiki, Japan 2Department of Gastroenterology, Kawasaki Medical School, Kurashiki, Japan 3Department of Endoscopy and Ultrasound, Kawasaki Medical School, Kurashiki, Japan 4Gastroenterology of Matsue Red Cross Hospital, Matsue, Japan 5Department of General Internal Medicine, Kawasaki Medical School, Kawasaki Hospital, Okayama, Japan Keyword: Helicobacter pylori , ペプシノゲン , ガストリン pp.64-71
Published Date 2016/1/25
DOI https://doi.org/10.11477/mf.1403200525
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 Serum pepsinogen(PG)levels reflect not only gastric atrophy but also levels of inflammation. Although PG levels have primarily been utilized for the detection of atrophy that has a high risk of evolving into gastric cancer, focusing on PG measurements may provide other benefits in the future. Patients who visited our hospital and were diagnosed with normal gastric mucosa without Helicobacter pylori infection, based on three tests(serum anti-H. pylori antibody levels, endoscopy, and histology), had PG I levels of 43.7±14.7ng/mL, PG II levels of 8.6±3.4ng/mL, a PG I/II ratio of 5.4±1.3, and serum gastrin levels of 64.3±28.4pg/mL. In the health checkup participants, the areas under the receiver operating characteristic curve for the diagnosis of H. pylori infection using the PG II levels and PG I/II ratio were as high as 0.942 and 0.958, respectively ; this indicated their advantages. The optimal cut-offs for the PG II levels and PG I/II ratio were 11.4ng/mL and 4.4, respectively. A simple serologic marker to capture the status of the gastric mucosa would be useful not only in the screening for gastric cancer but also for management of gastrointestinal disorders, including primary care.

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