Malignancy Developing in a Fundal Gland Polyp, Report of a Case Hiroyuki Ueda 1 , Shinji Nagata 1 , Kei Senoo 2 , Hidenori Tanaka 2 , Naoki Yorita 2 , Yuhei Saito 2 , Daiki Hirano 2 , Shunsuke Takata 1 , Kouji Waki 2 , Kenichi Kuwahara 2 , Shigeru Kimura 2 , Mayumi Kaneko 3 , Keiji Tsuji 2 1Department of Endoscopy, Hiroshima City Asa Hospital, Hiroshima, Japan 2Department of Gastroenterology, Hiroshima City Asa Hospital, Hiroshima, Japan 3Department of Laboratory medicine, Hiroshima City Asa Hospital, Hiroshima, Japan Keyword: 胃底腺ポリープ , 胃癌 , H. pylori陰性胃癌 pp.921-925
Published Date 2014/5/25
DOI https://doi.org/10.11477/mf.1403114183
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 We report the case of a 50-year-old male with several Yamada type II─III polyps measuring approximately 10mm in diameter in the gastric body. There was no evidence of background atrophy in the gastric mucosa, and microscopy, urea breath test, and anti-Helicobacter pylori antibodies were all negative. Because the possibility of malignancy could not be ruled out because of the irregular surface, the patient underwent endoscopic mucosal resection of 3 large polyps(>10mm)for the purpose of complete biopsy. Histopathological examination revealed all lesions to be fundal gland polyps, although one lesion exhibited a well-differentiated tubular adenocarcinoma on the surface. Subsequently, Ki-67 and p53 expression were demonstrated on immunostaining. Including the present case, we have experienced two patients with gastric cancer developing in a fundal gland polyp not associated with familial adenomatous polyposis. To the best of our knowledge, the present case was the first case of gastric cancer developing in a fundal gland polyp in an H. pylori-negative patient.

Copyright © 2014, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院