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Reflux Esophagitis and Barrett Esophagus in Elderly Patients Akiko Shiotani 1 , Takahisa Murao 1 , Hideaki Tsutsui 1 , Ken-ichi Tarumi 1 , Noriaki Manabe 2 , Jiro Hata 2 , Ken Haruma 1 1Division of Gastroenterology, Department of Internal Medicine Kawasaki Medical School, Kurashiki, Japan 2Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan Keyword: LSBE , 骨粗鬆症 , 食道裂孔ヘルニア , プロトンポンプ阻害薬 , NBI pp.1803-1810
Published Date 2012/11/25
DOI https://doi.org/10.11477/mf.1403113646
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 The prevalence of RE(reflux esophagitis)and Barrett esophagus has increased, however, the prevalence of LSBE(long segment Barrett esophagus)and Barrett adenocarcinoma is still low in Japan. The age-related risk factors for development of serious RE are deterioration of the LES(lower esophageal sphincter)function, complication of hiatal hernia, and decrease in peristalsis of the esophagus etc. Taking medicine inducing decrease of LES pressure in elderly patients and postmenopausal osteoporosis cause exacerbation of RE, and long-term maintenance therapy with PPIs(proton pump inhibitors)is often required in elderly patients with RE. However, epidemiology studies suggest a possible increased risk of bone fractures with the long-term use of PPIs. Although the definitions of Barrett esophagus and esophagogastric junction in Japan are different from those in Western countries, magnified endoscopy with NBI(narrow band imaging)seems to be useful for detecting SIM(specialized intestinal metaplasia), which is at high risk of progressing to esophageal adenocarcinoma.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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