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Clinical Features of Gastric Cancer Detected over 10 Years after Helicobacter pylori Eradication, Results from a Multi-Center Study Ken Haruma 1 , Susumu Take 2 , Akihito Nagahara 3 , Masanori Ito 4 , Haruhumi Oizumi 5 , Takayuki Matsumoto 6 , Kazunari Murakami 7 , Katsunori Iijima 8 , Mototsugu Kato 9 , Kazuhiko Inoue 10 , Yuichi Sato 11 , Kenji Tokumo 12 , Tomoari Kamada 1 1Department of Gastroenterology, Kawasaki Medical School, Kurashiki, Japan 2Department of Internal Medicine, Fukuwatari Hospital, Okayama, Japan 3Department of Gastroenterology, Jyuntendo University, Tokyo 4Department of Medicine and Molecular Science, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan 5Oizumi Clinic, Yamagata, Japan 6Department of Medicine and Clinical Scienece, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 7Department of Gastroenterology, Oita University Hospital, Yufu, Japan 8Department of Gastroenterology, Tohoku University, Sendai, Japan 9Department of Endoscopy, Hokkaido University Hospital, Sapporo, Japan 10Department of General Medicine, Kawasaki Medical School, Kurashiki, Japan 11Third Department of Internal Medicine, Niigata University Medical & Dental Hospital, Niigata, Japan 12Tokumo Clinic, Fukuyama, Japan Keyword: H. pylori感染 , 除菌 , 胃癌 , 診断 , 治療 pp.1623-1629
Published Date 2012/10/25
DOI https://doi.org/10.11477/mf.1403113616
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 Helicobacter pylori(H. pylori)infection is the most important factor in the pathogenesis of gastric cancer and the eradication of H. pylori is expected to prevent the development of gastric cancer. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. We investigated the clinical features of 26 gastric cancer patients detected over 10years after successful H. pylori eradication in a multi-center study. Gastric cancers discovered after H. pylori eradication were characterized as male dominant, early non-cardiac IIc-type cancers of the intestinal type without ulceration and whose patients had corporal atrophic gastritis before H. pylori eradication. Seven cases were surgically resected and 19cases were treated by endoscopic treatment. Our study revealed that careful follow-up endoscopic examination for possible gastric cancer is necessary even after successful H. pylori eradication in patients with early gastric cancer after endoscopic mucosal resection, gastric ulcer and atrophic gastritis, if such patients have baseline mucosal atrophy in the corpus.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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