Significance of Biopsy in the Diagnosis of Crohn's Disease Syuji Hamada 1 1Department of Gastroenterology, Fukuoka University Chikushi Hospital pp.611-622
Published Date 1986/6/25
DOI https://doi.org/10.11477/mf.1403110350
  • Abstract
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 Biopsy specimens obtained from 44 patients with Crohn's disease were histologically studied, with particular reference to the presence of granulomas and/or granulomatous lesions. These lesions were found in 18 cases (40.9%). Biopsy specimens taken from affected areas of the large intestine in 27 cases, contained epithelioid cell granulomas and/or granulomatous Iesions in 10 cases (37.0%), while those obtained from normal appearing colonic and rectal mucosa in 35 cases, did so in 11 cases (31.4%). Serial sections were made from the biopsy specimens taken from nomal appearing rectal mucosa in 11 cases, showing epithelioid cell granulomas and/or granulomatous lesions in as many as 9 cases (81.8%). Thus, high diagnostic yield is expected to result from the examination of serial sections of multiple biopsy specimens taken from multiple sites.

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