雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

Crohn's Disease Associated with Amyloidosis, Report of a Case Ryuichi Tsutsui 1 1The First Department of Internal Medicine, School of Medicine, Fukuoka University pp.195-201
Published Date 1988/2/25
DOI https://doi.org/10.11477/mf.1403107888
  • Abstract
  • Look Inside

 We report a case of amyloidosis which developed 7 to 9 years after Crohn's disease had been diagnosed. The case was a 28 year-old male who had abdominal pain and diarrhea for the first time in 1975 (at the age of 19) . He was diagnosed as having Crohn's disease at another hospital in 1977, and right hemicolectomy and distal ileal resection were performed because of severe stenosis. In October, 1980 he was referred and admitted to the First Department of Fukuoka University under diagnosis of relapse of Crohn's disease. Intestinal obstruction developed during hospitalization, and the remnant colon and ileum were resected in February, 1981. Amyloid deposition was not found on pathological study of the resected specimen. Serum level of creatinine had been within normal range until 1983 ; however, its increase was first recognized in February, 1984. In March,1985 serum creatinine went up 2.7 mg/dl with creatinine clearance being 20 ml/min. Urinary excretion of protein was 2 gm per day.

 Secondary amyloidosis was suspected based on these findings. Amyloid deposition was recognized on histological study of biopsy specimens from the stomach, small intestine and rectum. Although renal biopsy was not done, renal involvement was also suspected because of renal dysfunction and proteinuria.

 Liver, heart and thyroid functions were unremarkable. Analysis of amyloid protein in the biopsy specimens showed type AA frequently seen in secondary amyloidosis. Crohn's disease associated with amyloidosis is rare, and this case seems to be the third one ever reported in Japan.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有