Malignant Lymphoma of the Gastro-intestinal Tract: Report of 41 cases and review of the literature K. Nakamura 1 , H. Sugano 1 , K. Kumakura 2 , K. Takagi 3 1Dept. of Pathology, Cancer Institute 2Dept. of Int. Med., Cancer Institute Hospital 3Dept. of Surgery, Cancer Institute Hospital pp.177-186
Published Date 1973/2/25
DOI https://doi.org/10.11477/mf.1403108359
  • Abstract
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 A clinico-pathological study has been made of 41 cases of primary malignant lymphoma of the gatrointestinal tract resected at the Department of Surgery, Cancer Institute, during the past 26 years 1946-1971, together with a review of its literature.

 1. Of 41 cases, the stomach was the site of origin in 31 cases, small intestine in 3, colon in 2, and in 5 cases malignant lymphoma coexisted in the stmach and intestine. Of these 5 cases, 2 were regarded as double malignant lymphomas of the stomach and intestine. Its distribution in our series follows the same tendency seen in the literature. Its predilection sites are the stomach and the ileum. The colon is far less, and the rectum is least, often involved.

 2. Malignant lymphoma of the gastro-intestinal tract favors the age groups 50~69, as is the same with other malignant neoplasms of the gastrointestinal tract, but predilection of malignant lymphoma of the small intestine for small children has been reported in the literature.

 3. Of 41 cases of malignant lymphoma, reticulum cell sarcoma accounted for 35 cases, lymphosarcoma for 5 and Hodgkin's sarcoma for 1. In the literature the incidence of malignant lymphoma as classified according to histologic types shows that, as compared with Japan, lymphosarcoma is a little oftener encountered in the United States and Europe than reticulum cell sarcoma.

 4. Histologic differentiation of malignant lymphoma from hyperplasia of lymphoreticular hyperplasia has also been briefly discussed. This distinction forms the basis of solving the problem of malignant change of lymphoreticular hyperplasia. It remains to be solved in future.

 5. As for the question how gastric ulcer is involved in malignant lymphomatous change it, would be most appropriate to consider that the majority of lesions in which ulcer is in spatial overlapping with malignant lymphoma is caused by ulceration of lymphomatous growth.

 6. The prognosis of malignant lymphoma of the gastrointestinal tract is said in the literature to be better than its cancer. In our series of 41 cases, five-year survival was seen in 8 cases.

Copyright © 1973, Igaku-Shoin Ltd. All rights reserved.


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