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Systemic Lupus Erythematosus with Gastrointestinal Manifestation Report of an Autopsy Case M. Matsumoto 1 , K. Kataoka 2 , T. Sugihara , S. Akita , K. Motohara 3 1The Second Department of Pathology, Shiga University of Medical Science, School of Medicine 2Otsu Municipal Hospital 3Motohara Clinic pp.897-903
Published Date 1981/8/25
DOI https://doi.org/10.11477/mf.1403108163
  • Abstract
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 The patient, a 46year-old woman with systemic lupus erythematosus, had been treated for four years under a diagnosis of SLE and her general conditions had been temporarily improved. Then, abdominal symptoms, such as nausea, vomiting, epigastric pain and diarrhea, gradually developed. X-ray examinations of the gastrointes tinal canal revealed a marked swelling of the mucosal folds and a narrowing of the lumen of the small intestine. The colon showed increased spasticity. No ulcerative lesion was detected. The symptoms persisted without any improvement by antibiotica, steroids, and plasma or blood transfusions. The patient died about six months after the onset of abdominal impairment.

 On autopsy, pronounced edema of the whole gastrointestinal tract was disclosed. No circumscribed injuries were noticed except for dispersed foci of tiny ischemic necrosis in the ileocecal mucosa. Microscopically, vasculitis in active stage could not befound. Diffuse extensive fibrosis was observed in the peritoneal and subperitoneal tissues including the gastrointestinalwall. With special reference to this intraperitoneal fibrosis, the pathogenesis of persistent edema of the gastrointestinal canal is discussed.


Copyright © 1981, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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