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Multiple Ulcers of the Ileum Complicated with an Internal Fistula (Intestinal Behçet?) S. Kobayashi 1 , T. Kasugai 1 , T. Suchi 2 1Department of Internal Medicine, Aichi Cancer Center Hospital 2Department of Pathology, Aichi Cancer Center Hospital pp.1637-1641
Published Date 1978/12/25
DOI https://doi.org/10.11477/mf.1403107565
  • Abstract
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 A 66-year-old man was well until March 1975, when he developed hematemesis and melena. In July 1976, he developed right lower quadrant pain associated with a gradual weight loss.

 On physical examination, he was noted to have a firm, mobile, egg-sized mass with a smooth surface and slight tenderness in the ileocecal region.

 The patient was admitted to hospital for investigation.

 Barium enema and barium meal follow-through studies revealed an irregular mucosal pattern in the terminal ileum with a fistula between the ileal loops. The radiological impression was probably Crohn's disease of the ileum.

 However, because the possibility of tuberculosis or lymphoma could not be entirely ruled out. Ileocecal resection was performed. The resected specimen demonstrated multiple irregular ulcers and erosions with an internal fistula between the loops of the terminal ileum.

 Histologically, these ulcers were of non-specific inflammatory process, with deeply undermined edges, penetrating through the muscularis. The floor of ulcer shows granulation tissues rich in vascularity, containing maked cellular infiltrates of lymphocytes, plasma cells, histiocytes, neurophils and eosinophils. Foci of lymphoid tissues with hyperplastic germinal centers were seen scattered through the ileum near the ulcers. The histological pictures were not typical of Crohn's disease. Tuberculosis and other infectious etiology were unlikely.

 Postoperatively, ESR did not improve five weeks after operation. Four months later, he developed dearrhea and abdominal pain along the operative suture line. Barium enema at that time revealed a recurrent disease on the ileal side of the anastomosis. Since then, he has been treated with salazopyrin and predonisolone for one year and eight months. He is now in clinical remission

 During the follow-up period, he was suspected of having Behçet's disease because of grossly undermined appearance of the ulcers. However, the patient has not yet shown other signs of Behçet's disease than occasional aphthous stomatitis which can also be a complication of Crohn's disease.

 It has been reported that a trare occasions do typical of Behçet disease appear later than intestinal ulceration. A long-term follow-up should clarify the true nature of this patient's disease.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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