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A Case of the So-called Carcinosarcoma associated with Prominent Stromal Reaction K. Tominaga 1,2 , K. Futazuki 3 , K. Makiyama 3 , K. Matsunaga 3 , I. Hisamatsu 4 , M. Takahara 4 1Dept, of Pathology, Institute for Tropical Medicine, Nagasaki University 32nd Dept. of Internal Medicine, School of Medicine, Nagasaki University 4Zeshin Kai Tobo Hospital pp.467-473
Published Date 1976/4/25
DOI https://doi.org/10.11477/mf.1403107147
  • Abstract
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 Carcinosarcoma originating in the stomach is a rare disease. Opinion differs about its entity. There are many like Saphir who doubt its presence itself.

 A 63-year-old man visited us with a chief complaint of feeling of pressure in the epigastrium. As both x-ray and endoscopy suggested cancer, operation was performed. The resected stomach showed a tumor on the lesser curvature of the pyloric antrum associated with a large ulceration over it. The neoplasm reached the muscular coat in cut section. Histologically, tumor cells with monotonous sarcoma-like structure proliferated especially in the middle and lower layers of the tumor. Poorly differentiated tubular carcinoma was seen in the upper layers with a shifting change to sarcoma-like cells in between. In a part of the mucosa around the ulcer was seen highly differentiated tubular carcinoma, suggesting its link to the afore-mentioned carcinomatous part.

 These results may be construed as showing atypical carcinoma with more of sarcomatous picture than well differentiated carcinoma, but we arrived at a diagnosis of “the so-called Carcinosarcoma” on account of the peculiar histologic picture of sarcoma-like cells.

 Stromal reaction was recognized in the lower layers of the tumor as well as in the adjacent region, surrounding, as it were, the tumor. In spite of its large size, the tumor was localized with no lymph node metastasis. As of this writing, more than 5 years after the operation no recurrence is seen. Stromal reaction may play a part in prognosis.


Copyright © 1976, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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