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Early Esophageal Carcinoma Associated with Dermatomyositis, Report of a Case S. Katsushima 1 , T. Honda 1 , Y. Kawaguchi 1 , G. Terashima 2 , Y. Naito 3 , E. Aoki 4 1The First Department of Internal Medicine. Osaka Teishin Hospital 2Department of Surgery, Osaka Teishin Hospital 3Department of Dermatology, Osaka Teishin Hospital 4Department of Radiology, Faculty of Medicine, Kyoto University pp.565-570
Published Date 1984/5/25
DOI https://doi.org/10.11477/mf.1403107034
  • Abstract
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 Coincidence of esophageal cancer with dermatomyositis is rare. Only seven cases have been reported for these 25 years in Japan. In this paper, we report the first case of early esophageal carcinoma associated with dermatomyositis.

 A 56 year-old man was admitted to our hospital with a complaint of diffuse erythema on the forehead, neck and upper chest since Dec. 1981. Also he had edematous erythema on the nape and back, teleangiectasis on the nail bed and muscle weakness of the shoulder girdle and thigh. Laboratory examinations were following; SGOT 85 U/l, LDH 488 U/l, CPK 345 U/l, ESR 28 mm in first hour, myogenic pattern in electromyogram. A biopsy specimen of the erythema taken from the upper chest showed atrophic epidermis, edema in the upper part of the corium and mild infiltration of lymphocyte at perivascular area.

 Roentgenological and endoscopical examinations of the esophagus revealed a well-defined superficial elevated lesion on the right side of the posterior wall of Im region (middle thoracic esophagus). It was diagnosed as esophageal cancer. The tumor was surgically resected.

 In the resected specimen, the lesion was 15×15 mm in diameter and had nodular surface with central depression. Histopathological examinations confirmed the lesion to be a superficial elevated type early esophageal cancer which was moderately differenciated squamous cell carcinoma and limited to the mucosa and submucosa with no lymph node metastasis.

 After operation, erythema was improved by oral administration of gluco-corticoid. The patient has not been treated by any anti-cancer therapy because of no evidence of the invasion into blood vessels and lymphatics. Thirteen months later, the recurrence was found on cervical and mediastinal lymph nodes. Even though there was no evidence of metastasis at the surgical resection, clinical courses are suggesting us the necessity of anti-cancer therapy after surgical resection especially in the case of moderate differenciated early esophageal cancer.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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