Granular Cell Tumor of the Stomach, Report of a Case T. Hamada 1 , K. Nagao 1 , T. Shojima 1 , S. Hori 1 , S. Nakagaki 1 , H. Yamamoto 1 , H. Takegawa 2 , M. Takemiya 3 1Department of Surgery, Kumamoto Municipal Hospital 2Department of Internal Medicine, Kumamoto Municipal Hospital 3The Second Department of Pathology, School of Medicine, Kumamoto University pp.77-82
Published Date 1984/1/25
DOI https://doi.org/10.11477/mf.1403106934
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 The patient, a 46-year-old woman complaining of epigastric dull pain, was diagnosed to have a gastric polyp four years ago.

 She has been almost asymptomatic up to date. Recently, she visited our clinic for examination of the gastric polyp. Radiologic and endoscopic examinations of the gastrointestinal tract revealed a polypoid lesion at the posterior wall and the middle body of the stomach. The lesion showed a depression at the top of the tumor and a bridging fold. The findings were considered as a submucosal tumor. We recommended her for operation because gastric carcinoid was suspected. Radical distal gastrectomy was performed and the resected specimen showed a polypoid lesion,13×10 mm in diameter,7 mm in height. Perpendicular section of the tumor was yellowish-white and clearly lined submucosal mass. Microscopically small nuclei and granular cytoplasms were observed in the tumor nest. Granules stained with PAS reagent, not digested for amylase, were seen in the cytoplasm. Electron micrograph of tumor cells showed membrane-delimited granules in the cytoplasm. Tumor cells exhibited a positive reaction with CEA immunohistochemical reaction by the PAP and with S-100 protein immunostaining. These findings lend substantial support to the opinion that the granular cell tumor is of Schwann cell origin.

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