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Granular Cell Tumor of the Esophagus, Report of a Case T. Kamata 1 , M Hatayama 1 , T. Arakawa 1 , K. Kobayashi 1 , Y. Hamanaka 2 , H. Osugi 2 , Y. Kobayashi 2 1The Third Department of Internal Medicine, Osaka City University, Medical School 2The Second Department of Surgery, Osaka City University, Medical School pp.1005-1009
Published Date 1980/10/25
DOI https://doi.org/10.11477/mf.1403112802
  • Abstract
  • Look Inside

 The patient, a 44 year-old man, had a complaint of dysphagia and was examined in our clinic.

 Roentgenologic and endoscopic findings demonstrated a smooth, yellowish-white and well-defined elevation at the left side of the middle esophagus. Biopsy specimens taken from the lesions disclosed the tumor cells with intracytoplasmic eosinophilic granules growing in the subepithelial layer and the overlying epithelium accompanied with pseudoepitheliomatous hyperplasia.

 The ultrastructural findings of the present case were as follows.: 1) Tumor cells had numerous acidophilic cytoplasmic granules which were double membranebound and contained granular material, myelin substance and multivesicular bodies. 2) These tumor cell clumps were surrounded by basement membranes.

 So, these morphological studies revealed granular cell tumor and suggested Schwann cell histogenesis.

 The lesion were enucleated after being comfirmed to localize under the tunica propria mucosae on the roentgenogram with injected Myodil into the submucosal layer.

 Resected tumor was yellowish-white, measuring 25×17×7 mm. And its lesion was comfirmed histologically to have no invasion into the submucosal layer.

 To our knowledge only nineteen cases of this tumor were reported in the world literature and the present case was its 20 th.


Copyright © 1980, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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