Clinicopathological Study of the Creeping Tumor and Specificity of Gene Products from Results of Immunostaining Takahiro Fujimori 1 1The Second Department of Pathology, Kobe University School of Medicine Keyword: 結節集簇様大腸病変 , 免疫染色 , ras遺伝子 , p53遺伝子 pp.399-407
Published Date 1992/4/25
DOI https://doi.org/10.11477/mf.1403106782
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 In order to investigate the different mechanism between the creeping tumor and tumor induced by the usual adenoma-carcinoma sequence, products of ras gene and p 53 gene were stained immunohistologically in 18 creeping tumors which were diagnosed eudoscopically. Moreover, these clinicopathological characteristics were studied and compared with cases shown in literature. Ras-positivity was seen in 36% cases of type B adenoma (less than 2 cm of maximum diameter) region, and in 71% of the cancers. Ras-positivity was seen in type A adenoma (2 cm or more of maximum diameter) region in 29% cases and in the cancer region in 50% cases. No case showed p 53-positivity. These results were considered to be almost identical to the results of ras-positivity and p 53-positivity obtained from the usual adenoma-carcinoma sequence.

 It was speculated that the difference of the positive rate reflected only differences of atypical degrees and the creeping tumors developed in the same mechanism of the usual carcinogenesis of the colon cancer, regardless of morphological specificity and size of tumor. Type B is induced by abnormalities of ras genes and p 53 genes in early shift to the next step, and tumor character which reveals horizontal extension are changed. On the other hand, it was assumed with respect to type A that the tumor character showing horizontal extension was maintained because similar steps occurred at a late stage for a long period. In terms of clinicopathological characteristics, the cases which have a relatively large (2 cm or more) and low elevated lesion with granular surface might be considered to be contained in one category. However, it was found that our type A cases had a lower complication rate of m, and sm cancer in comparison with cases shown in the literature. For quality diagnosis of the lesions, the surface structure of the lesion was considered to be important. Regarding the name, in order to place the tumor as one which does not show malignancy, namely, deep invasion, and is conglomerated with slow-invasive low elevation, we proposed to call it the creeping tumor with a different meaning from superficial type cancer.

Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.


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