腺境界と胃病変―腺境界の識別法と腺境界の局在に関連する諸因子を中心に

Grandular Border and Gastric Lesion: Regarding how to recognize the glandular border and factors affecting its loca1ization

　胃は，異なった形態と機能を持つ粘膜の隣接によって胃底腺・幽門腺境界，十二指腸・幽門腺境界，噴門腺・胃底腺境界の各腺境界を有している．なかでも近年，各種の胃疾患の背景胃粘膜として，胃底腺および幽門腺の各領域に関する研究が盛んとなり，腺箋界，萎縮境界，移行帯，中間帯などの名称で呼ばれる胃底腺・幽門腺境界は，多くの研究者の興味を集めてきた．本稿では，胃底腺・幽門腺境界（以下，腺境界と呼ぶ）の識別法にまず触れ，次いで腺境界の局在に関連する諸因子や特定の病態との関係について，われわれの成績をもとに述べる．

　Grandular border between antral and fundic gland is not only the junction of two different gastric mucosae but also the place contributing pathogenesis of various gastric lesions, and furthermore its localization may change even under the physiological condition (e.g. aging). Therefore, it is extremely important to improve its recognizing method to have the high agreement in tissue level. Here we discussed our results concerning how to recognize the glandular border. We feel that if we follow an aging change of the border in the same person or classify the factors affecting its localization by using more accurate method, we’ll be able to clarify the relationship between the glandular border and the background gastric mucosa as well as pathogenesis of the various gastric lesions.