食道・大腸にアフタ様潰瘍を認めサラゾスルファピリジンが著効を示した腸型Behget病疑診の1例

Probable Intestinal Behget's Disease with Esophageal and Colonic Aphthoid Ulcers, Successfully Treated wih SASP, Report of a Case

要旨　患者は25歳，女性．咽頭痛，下痢，発熱を主訴として来院口腔内にアフタの多発を認め，針反応も陽性であった．回盲部・上行結腸に深い不整形潰瘍の多発，横行結腸～直腸にかけて連続性にアフタ様潰瘍，また食道にもアフタ様潰瘍を認めた．病変部の生検組織所見ではいずれも非特異的な炎症所見を認めるのみであった．腸型Behget病が疑われ，サラゾスルファピリジン（4.Og）投与により症状が軽快し，大腸および食道病変も著明な改善をみた1例を報告する．

　A 25-year-old female visited our clinic complaining of sore throat, diarrhea and fever. She had aphthoid ulcers in the oral cavity and was positive in needle reaction of the skin. Barium enema, upper gastrointestinal endoscopic and colonoscopic examinations revealed multiple irregular-shaped ulcers in the cecum and the ascending colon. There were aphthoid ulcers in the transverse, descending, sigmoid colon, the cecum, and the midesophagus. Biopsy specimen obtained from the mucosal lesions of the colon and the esophagus showed nonspecific inflammation. Intestinal Behget's disease was suspected. He rsymptoms and ulcerative lesions completely disappeared with one month's treatment of salicylazosulfapyridine (SASP) 4.Og per day.