Pathological Aspect of Early Gastric Carcinoma, Handling of the Endoscopically Mucosectomized Specimen and Problems in the Pathological Diagnosis Morio Koike 1 , Touichirou Takizawa 1 , Yoshiaki Iwasaki 1 1Department of Pathology, Tokyo Metropolitan Komagome Hospital Keyword: 早期胃癌 , 切除標本 , 内視鏡的粘膜切除 , 生検診断 pp.127-138
Published Date 1993/2/26
DOI https://doi.org/10.11477/mf.1403106094
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 Early cancer of the stomach has had the majority in the resected gastric carcinoma. A surgically resected stomach is to be handled by“the general rules for gastric cancer study”, but there are differences in handling a resected specimen among institutes. Endoscopic mucosectomy is now widely performed on a small early carcinoma, especially, an elevated, type Ⅱa, less than 1 cm in size, and histologically well differentiated type lesion. As the procedure becomes common, its indication seems to expand. However, there is no general agreement of how to deal with a mucosectomized specimen. The objective of endoscopic mucosectomy is curative resection of early carcinoma. The resected specimen should be well fixed for the purpose of examining its margin and the depth of invasion to confirm the completeness of resection. We demonstrated how to fix and observe a specimen for stereomicroscopic examination using photographs.

 There are some pathological problems in diagnosing a gastric biopsy specimen. We showed photographs of the following lesions: an adenoma of small intestinal type and regenerative atypia which needed to be differentiated from a well differentiated adenocarcinoma; a well differentiated adenocarcinoma of foveolar epithelial type and a carcinoma mimicking intestinal metaplasia, which were difficult to diagnose. Molecular biological investigations on such lesions are in progress.

Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.


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