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Prospective Observation of Superficial Colorectal Neoplasms Jiro Watari 1,2 , Yusuke Saito 2 , Yutaka Orii 1 1Department of Gastroenterology, Asahikawa Kosei Hospital 2he Third Department of Internal Medicine, Asahikawa Medical College Keyword: 表面型大腸腫瘍 , prospective study , 自然史 , Ki-67 , apoptosis pp.1599-1606
Published Date 1996/12/25
DOI https://doi.org/10.11477/mf.1403104467
  • Abstract
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 Superficial type neoplasm is a relatively new category of colorectal tumor. Compared with sessile tumor, it has been speculated that this type of adenoma easily evolves into carcinoma and invades the submucosal layer early even in a small size. The direct evidence of this speculation has, however, not been presented so far. Furthermore, no data has been offered on the mode of their growth, i.e. whether or not the superficial type neoplasms develop into invasive cancer in keeping with their macroscopic shapes. We followed up 45 colorectal neoplasms (38 superficial and seven sessile types, 33 adenomas, three carcinomas and nine tumors of undefinite histology) by colonoscopic observation and biopsy for 15.1 (1~42) months. A cell kinetic data was also analyzed by detecting proliferating cell growth fraction (%GF) and cell loss fraction by apoptosis (%Apo). Tumor size did not change during the follow-up period. Of 38 superficial type neoplasms, follow-up colonoscopic examination showed unchanged figure in 18, elevated growth in 14, depressed growth in three, and disappearance in three. One of seven sessile tumors developed depressed growth, but the others were not changed. Sessile tumors had a higher %GF/%Apo ratio than superficial type neoplasms. Superficial type tumors with elevated growth during the follow-up period also had a higher %GF/%Apo ratio than those with depressed growth or unchanged figure. These results suggest that the superficial type adenomas tend to elevate during their growth, which are due to relatively higher proliferation against apoptotic cell loss.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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