Liver Metastasis from the Patients Who Underwent Gastrectomy for Primary Gastric Carcinoid Tumor after Long Surveillance, Report of a Case Takuji Gotoda 1 , Hitoshi Kondo 1 , Noriaki Hasuike 1 1Department of Endoscopy, National Cancer Center Hospital Keyword: 胃カルチノイド , 内分泌細胞癌 , 肝転移 , 予後 , 生物学的悪性度 pp.1429-1434
Published Date 2000/10/25
DOI https://doi.org/10.11477/mf.1403104900
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 A 62-year-old female was found to have a polypoid lesion of which 10 mm in size on the lower gastric body by the health check in previous hospital on april,1974. A small submucosal tumor with cental depression was detected by endoscopic examination in our hospital. The patient was admitted to our surgical division to undergo gastrectomy because carcinoid tumor was histologically confirmed by biopsy. On admission, the patient was in good condition and laboratory data including endocrinological findings were within normal limits.

 The patient received subtotal gastrectomy with lymph node dissection. Gastric carcinoid tumor invading submucosa was diagnosed on the resected specimen. Although the tumor was mainly composed of uniform cells with small round nuclei so called classical type carcinoid tumor, the cells with large round nuclei with a few mitosis were also shown in a part.

 Endocrine cell tumor has been classified as classical type carcinoid and endocrine cell carcinoma. Classical type carcinoid is generally composed of uniform cells with small round nuclei which is low grade atypia and less invasive, namely low malignancy biologically. Regardless of classical type carcinoid, however, there are some reports that metastasis from the patients with that tumor is led after long surveillance. In our case, the cells with large round nuclei and a few mitosis were recognized in a part of the tumor. The existence of these findings might lead liver metastasis after 8 year periods.

 Although classical type carcinoid is basically low malignant tumor, our experience suggests that this tumor should be carefully treated as gastric cancer.

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