Japanese

Histopathologic Characteristics of Ulcerative Colitis-associated Colorectal Epithelial Neoplasia Yoichi Ajioka 1 , Hidenobu Watanabe 2 , Tsunehisa Kano 3 1Division of Molecular and Functional Pathology, Department of Cellular Function, Graduate School of Medical and Dental Sciences, Course of Molecular and Cellular Medicine, Niigata University 2Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Course of Molecular and Cellular Medicine, Niigata University 3Division of Gastrointestinal and General Surgery, Graduate School of Medical and Dental Sciences, Course of Molecular and Cellular Medicine, Niigata University Keyword: 潰瘍性大腸炎 , 大腸癌 , colitic cancer , dysplasia , 病理組織診断 pp.956-970
Published Date 2002/6/25
DOI https://doi.org/10.11477/mf.1403104494
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 Intramucosal neoplasias associated with ulcerative colitis (UC) were diagnosed either as adenocarcinoma or adenoma. Adenocarcinoma were classified into the following four histologic patterns ; ① common type, ② superficially differentiated type, ③ BC type (basal cell proliferation) or ④ PC type (pancellular dysplasia) . Carcinoma with low-grade atypia were frequent. UC-associated invasive colorectal carcinomas (CRC) included various histologic types. Poorly differentiated type, signet ring cell carcinoma, mucinous carcinoma, and well differentiated carcinoma with low-grade atypia were relatively frequent compared to those seen in sporadic CRC. It was suggested that UC-associaed CRCs with low-grade atypia have a high invasive potential unlike those in sporadic CRC. Although neither of the four histologic pattens indicated higher invasive potential, it is suggested that BC type might develop into CRC with a growth pattern different to those would develop from the other types.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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