Early Duodenal Cancer, Similar to Nodule-aggregating Lesions of the Colon and Occupying the Whole Lumen of the Duodenum, Report of a Case Susumu Eguchi 1 , Minoru Amano 1 , Masayuki Yamamoto 1 , Junji Irie 2 , Takashi Kanematsu 3 1Department of Surgery, Nagasaki Municipal Hospital 2Department of Pathology, Nagasaki Municipal Hospital 3Department of Surgery Ⅱ, Nagasaki University School of Medicine Keyword: 原発性十二指腸癌 , 結節集簇様病変 , 十二指腸腺腫 , 早期癌 pp.249-253
Published Date 1996/2/25
DOI https://doi.org/10.11477/mf.1403103954
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 A 78-year-old woman was admitted to our hospital because of nausea and vomiting. Upper gastrointestinal series revealed incomplete stenosis of the second portion of the duodenum and dilatation of the bulbar lesion. The final diagnosis obtained by biopsy revealed well differentiated adenocarcinoma. Pancreatico-duodenectomy was performed for the tumor. Macro-scopically, the tumor measured 9.0×6.0 cm in the size, occupying the whole lumen of the duodenum. Micro-scopically, adenocarcinoma limited to the submucosa and adenoma were observed partially along with the carcinoma. Immunohistochemically, they were negative for mutant p53 protein.

 Early duodenal cancer is relatively rare and, in size, this case is the largest early duodenal cancer to be reported in Japanese medical literature. Moreover, the symptom due to obstruction of the duodenum in this case is also rare for early cancer.

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